Attruby is a brand-name oral tablet that’s prescribed for transthyretin amyloid cardiomyopathy. Attruby contains the active ingredient acoramidis and belongs to the transthyretin stabilizer drug class.
Specifically, the Food and Drug Administration (FDA) has approved Attruby for use in adults to treat cardiomyopathy of variant or wild-type transthyretin-mediated amyloidosis to reduce the risk of hospitalization or death due to heart problems.
Drug details
You’ll find key information about Attruby below.
- Drug class: transthyretin stabilizer
- Drug form: oral tablet
- Generic available? no
- Prescription required? yes
- Controlled substance? no
- Year of FDA approval: 2024
- Accelerated approval? no
Attruby is available only as a brand-name medication. It’s not currently available in generic form.
A generic drug is an exact copy of the active ingredient in a brand-name medication. Generics usually cost less than brand-name drugs.
The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.
Drug form and strength
Attruby comes as an oral tablet in one strength: 356 milligrams (mg).
Dosage for transthyretin amyloid cardiomyopathy (ATTR-CM)
For treating ATTR-CM, the recommended Attruby dosage is 712 mg (two tablets) taken twice per day.
About taking Attruby
Below you’ll find information about key dosage issues.
- When to take: You should take Attruby twice per day, at the times instructed by your doctor. Taking the medication around the same time of day helps keep a steady level of the drug in your body. This helps Attruby work effectively.
- If you miss a dose: If you miss a dose, try to take it as soon as you remember. But if it’s almost time for your next dose, skip the missed dose. Do not take two doses at once, as doing so can raise your risk for Attruby side effects.
- Taking Attruby with food: You may take Attruby with or without food.
- Crushing, splitting, or chewing Attruby: Attruby tablets should be swallowed whole. You should not crush, split, or chew Attruby tablets. If you have trouble swallowing pills, talk with your doctor or pharmacist for advice.
- Length of use: Attruby is meant to be used as a long-term treatment. If you and your doctor determine that Attruby is safe and effective for you, you’ll likely take it long term.
- Length of time to work: Attruby begins working with your first dose. But you likely won’t feel Attruby working to lower your risk of hospitalization or death due to heart problems. Your doctor can provide more information on how they’ll monitor Attruby’s effectiveness during your treatment.
Overdose
Do not take more Attruby than your doctor recommends. For some drugs, doing so may lead to unwanted side effects or overdose.
What to do in case you take too much Attruby
If you think you’ve taken too much of this drug, call your doctor. You can also call America’s Poison Centers at 800-222-1222 or use its online tool. However, if your symptoms are severe, call 911 or your local emergency number or go to the nearest emergency room right away.
Attruby can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Attruby. These lists do not include all possible side effects.
For more information about the possible side effects of Attruby, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome.
Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Sharing your experience helps make medications safer for everyone by giving doctors and researchers more information about how the drug works in real life. If you develop a side effect while taking Attruby and want to tell the FDA about it, visit MedWatch or call 800-FDA-1088.
Mild side effects
Below is a partial list of mild side effects of Attruby. To learn about other mild side effects, talk with your doctor or pharmacist or view Attruby’s prescribing information.
Mild side effects of Attruby can include:
- diarrhea
- upper abdominal pain
- a mild increase in blood creatinine
Most of these side effects may go away within a few days to a couple of weeks. However, if they become more severe or don’t go away, talk with your doctor or pharmacist.
Serious side effects
Serious side effects from Attruby were not reported in clinical studies but are still possible. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or you think you’re having a medical emergency.
ALLERGIC REACTIONFor some people, Attruby oral tablets can cause an allergic reaction. But this side effect wasn’t reported in the drug’s studies.
In general, symptoms of allergic reaction can be mild or serious.
Ways to manage
For mild allergic reaction symptoms, such as a mild rash, call your doctor right away. They may recommend treatments to help manage your symptoms. They’ll also let you know whether you should keep taking the medication.
For severe allergic reaction symptoms, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms require immediate medical care because they can become life threatening. If you’ve had a serious allergic reaction to Attruby, your doctor may recommend taking a different medication instead.
The Food and Drug Administration (FDA) approves prescription drugs such as Attruby to treat certain conditions.
Attruby for transthyretin amyloid cardiomyopathy (ATTR-CM)
Attruby is prescribed for use in adults to treat ATTR-CM. Specifically, it’s used for cardiomyopathy of variant or wild-type transthyretin-mediated amyloidosis to reduce the risk of hospitalization or death due to heart problems.
ATTR-CM is a rare condition that causes the heart muscle to thicken because a protein called transthyretin does not form properly. Misformed transthyretin can clump together (a process called amyloidosis) and collect in your heart muscle, causing it to become stiff and thickened. This affects your heart’s ability to properly pump blood.
Symptoms of ATTR-CM include:
- shortness of breath, especially when at rest
- swelling in your feet and legs
- irregular heartbeat
- heart palpitations
- coughing or wheezing
Attruby can interact with several other medications. It can also interact with certain supplements and certain foods.
Before taking Attruby, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you take. Sharing this information can help you avoid potential interactions.
Interactions with medications, foods, and supplements
Below is a list of medications and supplements that can interact with Attruby. There are no known food interactions with Attruby. This list does not contain all drugs that may interact with Attruby. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
| Medications that can interact with Attruby | • certain antiepileptics, such as carbamazepine (Tegretol, others) and phenytoin (Dilantin) • certain antiandrogens, such as apalutamide (Erleada) and enzalutamide (Xtandi) • celecoxib (Celebrex) • rifampin (Rimactane) • ritonavir (Norvir) and treatments that contain it, such as Paxlovid (nirmatrelvir/ritonavir) |
|---|---|
| Vitamins or supplements that can interact with Attruby | St. John’s wort |
Alcohol interaction
Alcohol is not known to interact with Attruby. But alcohol can worsen transthyretin amyloid cardiomyopathy, the condition Attruby is prescribed to treat. For this reason, your doctor may suggest avoiding or limiting alcohol consumption if you have this condition.
If you have questions about how much alcohol is safe to drink while taking Attruby, talk with your doctor or pharmacist.
As with all medications, the cost of Attruby can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.
Financial and insurance assistance: If you need financial support to pay for Attruby or need help understanding your insurance coverage, help is available. A program called ForgingBridges is available for Attruby. For more information and to find out whether you’re eligible for support, call 1-888-552-7434 or visit the program website.
Generic version: Attruby is not available in a generic form. A generic drug is an exact copy of the active ingredient in a brand-name medication. Generics tend to cost less than brand-name drugs.
Learn more about saving money on prescriptions.
Other drugs are available that can treat transthyretin amyloid cardiomyopathy (ATTR-CM). Some may be a better fit for you than others. If you’re interested in finding an alternative to Attruby, talk with your doctor. They can tell you about other medications that may work well for you.
Vyndamax and Vyndaqel (tafamidis) are similar to Attruby.
Other medications, such as antiarrhythmics, can be used to improve quality of life in people with ATTR-CM but do not treat the condition itself.
If you can become pregnant, consider the following information about pregnancy and breastfeeding.
Attruby and pregnancy
It’s not known whether Attruby should be taken during pregnancy. If you’re planning a pregnancy or can become pregnant, talk with your doctor before taking this medication.
Attruby and breastfeeding
It’s not known whether Attruby should be taken while breastfeeding. If you’re currently breastfeeding or planning to do so, talk with your doctor before taking this medication.
Here are answers to some frequently asked questions about Attruby.
How does Attruby compare vs Vyndamax?
Attruby and Vyndamax are similar medications. They’re both FDA approved to treat transthyretin amyloid cardiomyopathy (ATTR-CM). And they belong to the same group of drugs, called transthyretin stabilizers.
Vyndamax comes as an oral capsule, while Attruby is available as an oral tablet. Vyndamax is typically taken one per day, while Attruby is usually taken twice per day.
To learn more about how Attruby and Vyndamax compare, talk with your doctor or pharmacist.
How does Attruby work?
Attruby is prescribed to treat transthyretin amyloid cardiomyopathy (ATTR-CM). With this condition, a protein called transthyretin is misformed and can clump together (a process called amyloidosis). These clumps of misformed protein then collect in your heart muscle, causing it to become stiff and thickened. This affects your heart’s ability to properly pump blood.
Attruby works by stabilizing transthyretin. This slows down the breakdown of transthyretin and slows the rate at which misformed transthyretin proteins collect in your heart muscle.
To learn more about how Attruby works, talk with your doctor or pharmacist.
Before taking Attruby, discuss your health history with your doctor. Attruby may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if any of the following apply to you:
- a kidney condition, such as chronic kidney disease
- previous allergic reaction to this or a similar drug
- pregnancy
- breastfeeding
Note: For more information about the potential negative effects of Attruby, see the “Attruby side effects” section.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
