Augtyro (repotrectinib) is a brand-name oral capsule prescribed for certain tumors and non-small cell lung cancer. Augtyro has interactions with some other drugs and certain supplements. Examples include hormonal birth control and eletriptan (Relpax).

An interaction occurs when one substance causes another substance to have a different effect than expected.

To learn more about Augtyro’s interactions, keep reading. For additional information, including details about its uses, see this article about Augtyro.

Before you start treatment with Augtyro, tell your doctor and pharmacist which prescription, over-the-counter, and other medications you take. By sharing this information with them, you may help prevent possible interactions. (To learn whether Augtyro interacts with supplements, herbs, or vitamins, see the “Augtyro and other interactions” section.)

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Here’s a table of drugs that can interact with Augtyro. Keep in mind that this table doesn’t include all drugs that may interact with Augtyro. Some of these interactions are described in detail in “Drug interactions in depth.”

Drug class or drug nameDrug examplesInteraction result with Augtyro
hormonal birth control• ethinyl estradiol/desogestrel (Cyclessa, Kariva, others)
• ethinyl estradiol/drospirenone (Yasmin, Yaz, others)
• etonogestrel (Nexplanon)
• levonorgestrel (Kyleena, Mirena, others)
may make hormonal birth control less effective
certain seizure drugs• carbamazepine (Carbatrol, Tegretol, others)
• phenobarbital (Sezaby)
• phenytoin (Dilantin, Phenytek)
may make Augtyro less effective
certain antibiotics• ciprofloxacin (Cipro)
• clarithromycin
erythromycin (Eryc, Ery-tab, others)
may increase the risk of side effects from Augtyro
certain antifungalsfluconazole (Diflucan)
• itraconazole (Sporanox, Tolsura)
ketoconazole
may increase the risk of side effects from Augtyro
certain antiarrhythmics• amiodarone (Nexterone, Pacerone)
• dronedarone (Multaq)
• quinidine
may increase the risk of side effects from Augtyro or make certain antiarrhythmics less effective
certain calcium channel blockers• diltiazem (Cardizem, Tiazac, others)
verapamil (Verelan, Verelan PM)
may increase the risk of side effects from Augtyro
budesonide (Tarpeyo, Uceris, others)may make budesonide less effective
buspironemay make buspirone less effective
eletriptan (Relpax)may make eletriptan less effective
nefazodonemay increase the risk of side effects from Augtyro

There aren’t any known interactions between Augtyro and alcohol. However, your doctor may advise you to avoid or limit alcohol consumption during Augtyro treatment.

This is because drinking alcohol while taking the drug may worsen some of Augtyro’s side effects. For example, you may have worsened dizziness, fatigue, or balance problems.

In addition, consuming large amounts of alcohol can cause liver damage. Augtyro may also cause liver damage as a side effect. This means that drinking alcohol during Augtyro treatment may increase the risk of liver damage.

If you have questions about drinking alcohol while taking Augtyro, talk with your doctor.

Here’s a closer look at certain drug interactions of Augtyro.

Hormonal birth control

Hormonal birth control is prescribed to help prevent pregnancy and for other uses.

Interaction result: Taking Augtyro with hormonal birth control could make the birth control less effective.

Interaction explained: Augtyro may speed up the breakdown of hormones in birth control. Taking these drugs together could cause the hormones to leave your body more quickly than is typical. This can lower the level of the hormones in your system, making the birth control less effective.

Examples of hormonal birth control drugs: Here are hormonal birth control options that may interact with Augtyro:

  • ethinyl estradiol/desogestrel (Cyclessa, Kariva, others)
  • ethinyl estradiol/drospirenone (Yasmin, Yaz, others)
  • etonogestrel (Nexplanon)
  • levonorgestrel (Kyleena, Mirena, others)

Steps you or your doctor may take: If you or a sexual partner can become pregnant, your doctor will likely recommend using nonhormonal birth control during Augtyro treatment. Examples include a condom, a diaphragm, and a copper intrauterine device (IUD).

For females, it’s recommended to continue using nonhormonal birth control for at least 2 months after the final dose of Augtyro. For males, doctors may advise using nonhormonal birth control for at least 4 months after the final dose.

To learn more about Augtyro and hormonal birth control, talk with your doctor or pharmacist.

Note: Sex and gender exist on spectrums. Use of the terms “female” and “male” in this article refers to sex assigned at birth.

Certain antifungals

Antifungals are prescribed to treat fungal infections.

Interaction result: Taking Augtyro with certain antifungals may increase the risk of side effects from Augtyro.

Interaction explained: Certain antifungals could slow the breakdown of Augtyro in your body. As a result, taking these drugs together could raise the level of Augtyro in your system. This could increase your risk of experiencing side effects from the drug.

Examples of antifungal drugs: Here are some antifungals that may interact with Augtyro:

Steps you or your doctor may take: If you need to take an antifungal during Augtyro treatment, be sure the doctor prescribing it knows that you’re taking Augtyro. They’ll advise you on whether the specific antifungal you need can be taken with Augtyro. Your doctor can tell you which antifungal may be best for your specific condition.

To learn more about Augtyro and antifungals, talk with your doctor or pharmacist.

Eletriptan

Eletriptan (Relpax) is prescribed to treat migraine episodes.

Interaction result: Taking Augtyro with eletriptan could make eletriptan less effective.

Interaction explained: Augtyro may speed up the breakdown of eletriptan in your system. Taking these drugs together could lower the level of eletriptan in your body, making the drug less effective.

Steps you or your doctor may take: Before taking Augtyro, be sure your doctor knows if you’re taking eletriptan. They can recommend whether it’s safe to take these medications together. If needed, they can recommend alternatives to either drug.

To learn more about Augtyro and eletriptan, talk with your doctor or pharmacist.

Augtyro may have other interactions, such as with supplements, foods, vaccines, or even lab tests. You’ll find details below. Keep in mind that the following information does not include all other possible interactions with Augtyro.

Augtyro interactions with supplements

Before you start treatment with Augtyro, tell your doctor and pharmacist which supplements, herbs, and vitamins you take. By sharing this information with them, you may help prevent possible interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Augtyro interactions with herbs

Augtyro may interact with St. John’s wort. This is an herbal supplement that is sometimes used for symptoms of depression and other conditions.

St. John’s wort may speed up the activity of an enzyme (a type of protein) in your body that helps break down Augtyro. This may lead to low levels of the drug in your system. If the level of Augtyro in your system is too low, the drug may not work as well to treat your condition.

If you take St. John’s wort, talk with your doctor before starting Augtyro treatment. They may be able to suggest an alternative to St. John’s wort.

Augtyro and vitamins

There are no specific reports of vitamins interacting with Augtyro. However, that doesn’t mean vitamin interactions won’t occur or be recognized in the future. Because of this, you should talk with your doctor or pharmacist before taking any vitamin product with Augtyro.

Augtyro interactions with food

Augtyro may interact with grapefruit and grapefruit juice.

This is because grapefruit products can slow the breakdown of Augtyro in your body. This may raise the level of Augtyro in your system, increasing your risk of side effects from the drug.

Due to this risk, your doctor may recommend avoiding grapefruit products while you’re taking Augtyro.

Augtyro and vaccines

There aren’t any known interactions between Augtyro and vaccines. You can talk with your doctor or pharmacist to see whether you’re due for any vaccines.

Augtyro and lab tests

Augtyro isn’t known to interact with any lab tests. If you have concerns about this medication interacting with lab tests, talk with your doctor.

AUGTYRO AND CANNABIS OR CBD

Cannabis (often called marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported to interact with Augtyro. However, as with any drug or supplement, talk with your doctor before using cannabis in combination with Augtyro. The impact of cannabis may affect how well you stick to your Augtyro treatment plan.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions and other factors may increase the risk of interactions with Augtyro. Before you take this drug, be sure to talk with your doctor about your health history. Augtyro may not be the right treatment option if you have certain medical conditions or other factors affecting your health.

Health conditions or factors that might interact with Augtyro include:

  • Gout: Treatment with Augtyro may cause high uric acid levels in the blood. This could worsen gout in people who already have this condition. If you have gout, your doctor can recommend whether Augtyro is a safe treatment option.
  • Liver problems: Before starting Augtyro treatment, tell your doctor if you have a liver problem such as liver failure. Augtyro may cause liver damage as a side effect, which could worsen your liver problem. Your doctor can recommend whether Augtyro is a safe treatment option.
  • Nervous system problems: If you have a problem with your nervous system, talk with your doctor before starting Augtyro treatment. The drug may cause side effects, such as difficulty with walking or balance, that could worsen symptoms of your condition. Your doctor can help decide whether Augtyro is safe for you.
  • Lung problems: Tell your doctor if you have a lung problem other than lung cancer (one of Augtyro’s approved uses). Augtyro may cause lung-related side effects that could worsen your condition. Talk with your doctor about whether Augtyro is right for you.
  • Allergic reaction: If you’ve had an allergic reaction to Augtyro or any of its ingredients, your doctor will likely not prescribe Augtyro. Taking the drug could cause another allergic reaction. You can ask them about other treatments that may be better choices for you.
  • Breastfeeding: It’s not known whether Augtyro passes into breast milk or whether the drug causes side effects in a child who is breastfed. To be safe, your doctor is likely to recommend that you avoid breastfeeding while taking Augtyro and for at least 10 days after your final dose. If you’re breastfeeding or planning to, talk with your doctor before taking Augtyro. They can talk with you about treatment options and ways to feed a child who is breastfed.
  • Pregnancy: There haven’t been enough clinical trials to determine whether Augtyro is safe to take while pregnant. Animal studies suggest that the drug may cause congenital anomalies (commonly known as birth defects). However, animal studies don’t always indicate what may happen in humans. To be safe, your doctor may advise you to use nonhormonal birth control while taking Augtyro and for several months after your final dose. (For details, see the “Drug interactions in depth” section.) If you’re pregnant or planning to become pregnant, tell your doctor before starting Augtyro. They can advise you on the right treatment plan.

You can take certain steps to help prevent interactions with Augtyro. Your doctor and pharmacist are key resources, so reach out to them before starting treatment. For example, you should plan to do the following:

  • Let them know if you drink alcohol or use cannabis.
  • Tell them about any other medications you take, as well as any supplements, herbs, and vitamins.
  • Create a medication listTrusted Source, which your doctor and pharmacist can help you fill out.

It’s also important to read the Augtyro label and other paperworkTrusted Source that may come with the drug. The label may have colored stickers that mention an interaction. And the paperwork, sometimes called the medication guide or patient package insert, may contain details about interactions.

If Augtyro doesn’t come with paperwork, you can ask your pharmacist to print a copy. If you need help reading or understanding this information, ask your doctor or pharmacist.

You can also help prevent interactions with Augtyro by taking it exactly as your doctor prescribes.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.