As with other drugs, Ebglyss (lebrikizumab-lbkz) can cause side effects, such as injection site reactions and pink eye. If you are not able to tolerate the side effects of Ebglyss, talk with your doctor or pharmacist.

Ebglyss (lebrikizumab-lbkz) is a brand-name injection that’s prescribed for moderate to severe atopic dermatitis (also called eczema) in certain adults and children ages 12 years and older.

If you have problems with the side effects from Ebglyss, talk with your doctor or pharmacist. They can discuss ways to manage side effects or suggest other available treatment options. Do not stop using Ebglyss without consulting your doctor first.

Ebglyss can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days to weeks. However, if the side effects persist, bother you, or become severe, be sure to talk with your doctor or pharmacist.

These are just a few of the more common side effects reported by people who took Ebglyss in clinical trials:

For more information about some of these side effects, see the “Managing side effects” section.

Mild side effects can occur with Ebglyss use. This list does not include all possible mild side effects of the drug. For more information, you can refer to Ebglyss’s prescribing information.

Mild side effects that have been reported with Ebglyss include:

  • injection site reactions, such as pain, itching, and rash
  • conjunctivitis (pink eye)

These side effects may be temporary, lasting a few days to weeks. However, if the side effects continue, worsen, or become too difficult to tolerate, be sure to talk with your doctor or pharmacist.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Sharing your experience helps make medications safer for everyone by giving doctors and researchers more information about how the drug works in real life. If you develop a side effect while using Ebglyss and want to tell the FDA about it, visit MedWatch or call 800-FDA-1088.

For more information about some of these side effects, see the “Managing side effects” section.

Ebglyss may cause serious side effects. The following list may not include all possible serious side effects of the drug. For more information, you can refer to Ebglyss’s prescribing information.

If you develop serious side effects while using Ebglyss, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Serious side effects that have been reported and their symptoms include:

  • shingles, which may include symptoms such as:
    • constant dull, burning, or gnawing pain, or a sharp, stabbing pain that comes and goes
    • skin rash that resembles a chickenpox rash but only affects certain areas
    • fluid-filled blisters
  • keratitis (inflammation of the cornea), which may include symptoms such as:
    • eye redness
    • eye pain
    • blurry vision
Allergic reaction

For some people, Ebglyss can cause an allergic reaction.

In general, symptoms of an allergic reaction can be mild or serious.

Ways to manage

For mild allergic reaction symptoms, such as a mild rash, call your doctor right away. They may recommend treatments to help manage your symptoms. They’ll also let you know whether you should keep receiving the medication.

For severe allergic reaction symptoms, such as swelling or difficulty breathing, call 911 or your local emergency number right away. These symptoms require immediate medical care because they can become life threatening. If you’ve had a serious allergic reaction to Ebglyss, your doctor may recommend a different medication instead.

While receiving Ebglyss, you may be able to take steps to make side effects easier to manage.

If you have problems with side effects that do not go away or they become worse, talk with your doctor or pharmacist. They can discuss options for managing side effects or other available treatment options.

Injection site reactions

Injection site reactions were common side effects reported in studies of Ebglyss. Examples of injection site reactions may include:

  • pain
  • itching
  • rash
  • swelling
  • warmth
  • skin discoloration

Steps you can take to manage symptoms associated with this side effect include:

  • taking OTC pain medications
  • applying a cold compress

Conjunctivitis (pink eye)

Conjunctivitis (pink eye) was a common side effect reported in studies of Ebglyss. Steps you can take to manage symptoms related to this side effect include:

  • use a warm, damp cloth to remove pus from the eyes and lashes
  • avoid touching eyes
  • prescription or over-the-counter (OTC) eye drops

Ebglyss may cause several side effects. Here are some frequently asked questions about the drug’s side effects and their answers.

How do side effects of Ebglyss compare with those with Dupixent?

Some side effects are similar, and some are different between Ebglyss and Dupixent. Ebglyss and Dupixent are both used to treat moderate to severe atopic dermatitis. Dupixent is approved for several other conditions, including moderate to severe asthma and chronic sinusitis.

Both drugs can cause injection site reactions and certain eye problems. Some side effects are different. For example, Dupixent can also cause an increased risk of cold sores, which Ebglyss does not.

If you have questions about side effects of these drugs, talk with your doctor or pharmacist. Also, to learn more about what to expect with Dupixent, see this article about Dupixent side effects.

Can Ebglyss cause long-term side effects?

It’s unlikely. Long-term side effects weren’t reported in studies of Ebglyss.

If you’re concerned about possible long-term side effects from Ebglyss, talk with your doctor or pharmacist.

Before receiving Ebglyss treatment, discuss your health history with your doctor. Ebglyss may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if any of the following apply to you:

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.