Abilify is a brand-name oral tablet prescribed for certain mood disorders, such as schizophrenia. Abilify contains the active ingredient aripiprazole and belongs to the antipsychotics drug class.
Specifically, the Food and Drug Administration (FDA) has approved Abilify to treat:
- schizophrenia in adults and children ages 13 years and older
- depression in adults, in combination with other medications
- manic and mixed episodes related to bipolar I disorder in adults and children ages 10 years and older, alone or in combination with other medications (lithium, for example)
- irritability related to autism in children ages 6 years and older
- Tourette syndrome in children ages 6 years and older
Drug details
The following list highlights key information about Abilify.
- Drug class: antipsychotics
- Drug form: oral tablet
- Generic available? yes
- Prescription required? yes
- Controlled substance? no
- Year of FDA approval: 2002
Other forms of Abilify
Abilify comes in other forms, including solutions for injection. This article does not discuss these other forms. If you have questions about other forms of Abilify, talk with your doctor or pharmacist.
Boxed warnings
Abilify has boxed warnings. A boxed warning is the most serious warning from the FDA. For details, see the “Abilify precautions” section.
Abilify is a brand-name drug that contains the active ingredient aripiprazole. This active ingredient is also available as a generic medication. A generic drug is an exact copy of the active ingredient in a brand-name medication.
The generic is considered to be as safe and effective as the original drug. Generics tend to cost less than brand-name drugs.
If you’re interested in using the generic form of Abilify, talk with your doctor. They can tell you if it comes in forms and strengths suitable for your condition.
The Abilify dosage your doctor prescribes will depend on several factors. These include:
- the type and severity of the condition you’re using Abilify to treat
- your age
- other medical conditions you may have
The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.
Drug form and strengths
Abilify comes as a tablet that you swallow. It’s available in the following strengths:
- 2 milligrams (mg)
- 5 mg
- 10 mg
- 15 mg
- 20 mg
- 30 mg
Dosage for schizophrenia
The starting dosage of Abilify for schizophrenia in adults is typically 10 to 15 mg once daily. If you’re still having symptoms of schizophrenia after 2 weeks of treatment, your doctor may increase your daily dose of Abilify.
The typical maintenance dosage of Abilify for schizophrenia is 10 to 30 mg daily. The maximum daily dose of Abilify for schizophrenia is 30 mg.
For information on Abilify dosage in children with schizophrenia, see the “Children’s dosage” section below.
Dosage for depression
Abilify is approved to treat major depressive disorder (MDD), which is also called depression, in adults. For this purpose, Abilify is used in combination with other drugs.
You’ll take Abilify in addition to other depression therapy. The typical starting dosage of Abilify for MDD is between 2 and 5 mg once daily. Then your dose will be increased by up to 5 mg each week until your depression symptoms decrease.
The typical maintenance dosage range of Abilify for MDD is between 2 and 15 mg daily. The maximum daily dose of Abilify for treatment of depression is 15 mg.
Dosage for manic and mixed episodes related to bipolar I disorder
Abilify is approved for use in adults with manic and mixed episodes related to bipolar I disorder.
For this condition, the typical starting dosage of Abilify in adults is 15 mg once daily. If you’re taking Abilify with either valproate or lithium, your doctor may recommend a starting dosage of Abilify of 10 to 15 mg once daily. (Valproate and lithium are other drugs used to treat bipolar disorder.)
The typical maintenance dosage of Abilify in adults with bipolar I disorder is 15 mg once daily. However, some people may require up to 30 mg of Abilify daily. And this is the maximum daily dose of Abilify for this condition.
For information on Abilify dosage in children with bipolar I disorder, see the “Children’s dosage” section below.
Dosage for irritability related to autism
Abilify is approved for use to treat irritability related to autism in children ages 6 to 17 years.
For information on Abilify dosages in children with irritability related to autism, see the “Children’s dosage” section below.
Dosage for Tourette syndrome
Abilify is approved for use in children ages 6 to 18 years old with Tourette syndrome.
For information on Abilify dosages in children with Tourette syndrome, see the “Children’s dosage” section below.
Children’s dosage
The following sections indicate the approved dosages of Abilify to treat children with certain conditions.
Dosage for schizophrenia in children
Abilify is approved for use in children ages 13 to 17 years with schizophrenia.
The typical starting dosage of Abilify for this use is 2 mg once daily. After 2 days of treatment, the child’s doctor may increase the daily dose to 5 mg. After an additional 2 days, the doctor may increase the Abilify dose to 10 mg daily.
Doses between 10 and 30 mg have been studied in children. Your child’s doctor will recommend a dosage of Abilify that’s right for your child.
Dosage for bipolar I disorder in children
Abilify is approved for use in children ages 10 to 17 years with manic or mixed episodes related to bipolar I disorder.
The typical starting dosage of Abilify for this use is 2 mg once daily. After 2 days of treatment, the child’s doctor may increase the daily dose to 5 mg. After an additional 2 days, their doctor may increase their Abilify dose to 10 mg daily.
If the doctor believes that your child needs a higher dose of Abilify, they may increase the dosage by 5 mg each day, up to a maximum of 30 mg daily.
Keep in mind that if your child is taking lithium or valproate along with Abilify, the recommended dosages of Abilify are the same as those previously described. (Lithium and valproate are other drugs used to treat bipolar disorder.)
Dosage for irritability related to autism in children
Abilify is approved for use in children ages 6 to 17 years with irritability that’s related to autism.
The typical starting dosage of Abilify for this use is 2 mg once daily. After at least 1week, the daily dose can be increased to 5 mg daily. Following this, the daily dose can be increased to 10 to 15 mg daily. It’s recommended to wait at least 1 week before increasing Abilify’s dosage.
The typical maintenance dosage range of Abilify for this use is 5 to 15 mg daily.
Dosage for Tourette syndrome in children
Abilify is approved for use in children ages 6 to 18 years with Tourette syndrome.
The starting dosage of Abilify for this use is based on the child’s body weight, as follows:
- If your child weighs less than 50 kilograms (about 110 pounds), their starting dosage of Abilify will be 2 mg daily. Then after 2 days, their doctor will increase the dosage to 5 mg daily. If after 1 week your child is still having symptoms of Tourette syndrome, their doctor may increase the dose to 10 mg daily.
- If your child weighs 50 kg (about 110 lb) or more, their starting dosage of Abilify will be 2 mg daily. Then after 2 days, their doctor will increase the dosage to 5 mg daily. After 5 days, your child’s doctor will increase their dosage to 10 mg daily. If your child is still having symptoms of Tourette syndrome, their doctor may increase their dose to a maximum daily dose of 20 mg.
About taking Abilify
The following list highlights some information about taking Abilify.
- When to take: The manufacturer of Abilify hasn’t stated the best time of day to take the drug. But taking the medication around the same time of day helps keep a steady level of the drug in your body. This helps Abilify work effectively.
- If you miss a dose: If you miss a dose, take the missed dose as soon as you remember. But if it’s almost time for your next dose, just skip the missed dose. Then take your next dose at the usual time. Never take two doses at once to make up for a missed dose.
- Taking Abilify with food: You can take Abilify with or without food.
- Crushing, splitting, or chewing Abilify: Abilify oral tablets should be swallowed whole. You should not crush, split, or chew them.
- Length of use: Abilify is meant to be a long-term treatment. If you and your doctor determine that Abilify is safe and effective for you, you’ll likely take it long term.
Overdose
Taking more than the recommended dosage of Abilify can lead to serious side effects. Do not take more Abilify than your doctor recommends.
Overdose symptoms
Symptoms of an Abilify overdose can include:
- vomiting
- sleepiness
- tremors or convulsions
- aggression
- heart problems, such as atrial fibrillation (a type of abnormal heart rhythm) and increased heart rate
- changes in certain blood tests, such as those used to check your liver and kidney function
- increased or decreased blood pressure
- loss of consciousness
- breathing that slows down or stops completely
What to do in case of overdose
If you think you’ve taken too much of this drug, call your doctor. You can also call America’s Poison Centers at 800-222-1222 or use its online tool. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away.
Abilify can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Abilify. These lists don’t include all possible side effects.
For more information on the possible side effects of Abilify, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be bothersome.
Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Sharing your experience helps make medicines safer for everyone by giving doctors and researchers more information about how the drug works in real life. If you develop a side effect while taking Abilify and want to tell the FDA about it, visit MedWatch or call 800-FDA-1088.
Mild side effects
The following list highlights some of the mild side effects of Abilify. To learn about other mild side effects, talk with your doctor or pharmacist, or see Abilify’s prescribing information.
Mild side effects of Abilify can include:
- nausea, vomiting, or constipation
- memory loss
- headache
- blurry vision or dizziness
- upper respiratory infection, such as a cold
- anxiety
- feeling sleepy or having insomnia
- restlessness or feeling like you need to move
- rash
- hair loss
- sexual side effects, such as sexual urges or changes in libido
Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.
Serious side effects
Serious side effects from Abilify aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency.
Serious side effects and their symptoms can include:
- Stroke in older people with psychosis that’s related to dementia. Symptoms may include:
- numbness or weakness on one side of your body
- feeling confused
- trouble walking
- Neuroleptic malignant syndrome, which may include symptoms such as:
- high fever
- rigid muscles
- Changes in your metabolism, such as diabetes or high cholesterol. Symptoms may include:
- feeling very thirsty or hungry
- being confused
- gaining weight
- Feeling the urge to do unusual things or excessively do certain things. Symptoms may include:
- binge eating
- gambling
- compulsive shopping
- sexual urges
- Decreased blood pressure when you’re standing up or sitting up, which can lead to falls. Symptoms may include:
- dizziness
- fainting
- Decreased level of white blood cells or neutrophils (a specific type of white blood cell). Symptoms may include:
- fever
- infections that don’t go away
- Impaired ability to think or move. Symptoms may include:
- feeling tired
- trouble thinking clearly
- decreased motor skills
- Problems with your body’s temperature control, which may include symptoms such as:
- sweating
- redness
- Trouble swallowing, which may include symptoms such as:
- pain when swallowing
- feeling like food is stuck in your throat
- heartburn
- Extrapyramidal disorder (a movement disorder caused by certain medications). Symptoms may include:
- trouble speaking
- anxiety
- Other movement disorders, such as tremors or tardive dyskinesia (TD).
- Increased risk of death in certain older people.*
- Suicidal thoughts and behaviors in younger people.*
* Abilify has a boxed warning for this side effect. This is the most serious warning from the FDA. To learn more, see the “Abilify precautions” section below.
Side effects in children
Common side effects of Abilify seen in children using the drug include:
- feeling sleepy
- tremors
- fatigue
- nausea or vomiting
- fever
- feeling restless
- blurry vision
- dizziness
- drooling or having more saliva than usual
- changes in appetite
- headache
- stuffy nose
- insomnia
- weight gain
- muscle stiffness
ALLERGIC REACTIONAs with most drugs, some people can have an allergic reaction after taking Abilify. But it’s not known how many people had an allergic reaction to Abilify during clinical trials of this drug.
Symptoms of a mild allergic reaction can include:
A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:
- swelling under your skin, typically in your eyelids, lips, hands, or feet
- swelling of your tongue, mouth, or throat
- trouble breathing
Call your doctor right away if you have an allergic reaction to Abilify, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.
Read more about Abilify’s side effects.
The Food and Drug Administration (FDA) approves prescription drugs such as Abilify to treat certain conditions. Abilify may also be prescribed off-label for other conditions. Off-label use is when a drug that’s approved to treat one condition is used to treat a different condition.
Abilify for depression
Abilify is approved for use with antidepressants in adults with major depressive disorder (MDD). Examples of antidepressants include escitalopram (Lexapro), sertraline (Zoloft), and venlafaxine XR (Effexor XR).
MDD, which is often called depression, is a serious disease that affects your mood and actions. People with MDD often feel sad or anxious. This condition may affect your daily life, and you possibly may not be able to eat or sleep like usual.
Other symptoms of depression include feeling hopeless and not having an interest in activities that you used to enjoy. Some people with depression may have suicidal thoughts or behaviors, which are serious and may be life threatening.
If you have new or worsening symptoms of depression, talk with your doctor right away. Your doctor can recommend treatment options, which may include Abilify.
Abilify for manic and mixed episodes related to bipolar I disorder
Abilify is approved to treat manic or mixed episodes related to bipolar I disorder. For this use, Abilify can be given to adults and some children. For this condition, Abilify is approved for use on its own. It’s also approved for use in combination with either valproate or lithium. (Valproate and lithium are other drugs used to treat bipolar disorder.)
Bipolar disorder affects your brain and causes you to have changes in your mood and behavior. With bipolar I disorder, you may have manic episodes. During these episodes, you can feel energetic or extremely irritable. And your thoughts may be racing, making it difficult for you to concentrate.
It’s also possible to have mixed episodes with bipolar I disorder. During mixed episodes, you have manic symptoms and depression symptoms at the same time.
Symptoms of depression can include feeling sad or hopeless or lacking interest in activities that you used to enjoy. Some people with depression may have suicidal thoughts or behaviors, which are serious and may be life threatening. With mixed episodes, you can have changes in your mood that can be severe.
Abilify for schizophrenia
Abilify is approved to treat schizophrenia in adults and some children. Schizophrenia is a disorder that affects how you think and behave.
Many different things can cause schizophrenia. These include genetics and changes in certain neurotransmitters (brain chemicals).
Usually, schizophrenia begins to affect people during their teenage or young adult years. Symptoms of schizophrenia vary, but they can include:
- Positive symptoms: These symptoms are thoughts or behaviors that happen in people with schizophrenia but don’t happen in people without the disease. Examples of positive symptoms include hallucinations, unusual thoughts, and changes in body movements.
- Negative symptoms: These symptoms also affect your behavior. They may cause you to have very little or no emotion. And you may also not want to talk as often as usual.
- Symptoms that affect your memory and ability to think: These symptoms include difficulties with attention, remembering things, and staying focused.
Abilify for irritability related to autism
Abilify is approved to treat irritability related to autism in some children. For more information, see the “Abilify and children” section below.
Abilify for Tourette syndrome
Abilify is approved to treat Tourette syndrome in some children. For more information, see the “Abilify and children” section.
Abilify for other conditions
In addition to the uses listed above, Abilify may be prescribed off-label for other uses. Off-label drug use is when a drug that’s approved for one use is prescribed for a different one that’s not approved. If you have questions about off-label uses of Abilify, talk with your doctor or pharmacist.
Abilify and children
Abilify is approved for use in some children with certain mental health conditions. The following table lists these conditions.
Condition Abilify treats in children | Age range | Use with other drugs |
schizophrenia | ages 13 years and older | may be used on its own or in combination with other drugs if a doctor recommends it |
manic or mixed episodes related to bipolar I disorder | ages 10 years and older | may be used on its own or in combination with either valproate or lithium |
irritability that’s related to autism | ages 6 years and older | may be used on its own or in combination with other drugs if a doctor recommends it |
Tourette syndrome | ages 6 years and older | may be used on its own or in combination with other drugs if a doctor recommends it |
Keep in mind that Abilify may increase the risk of suicidal thoughts and behaviors in children and young adults ages 24 and younger. (See the “Abilify precautions” section for more information.) Because of this risk, Abilify should be used cautiously in people ages 24 and younger.
Abilify has only been studied in adults, not children, with major depressive disorder (MDD). Because of this, it’s not known if the drug is safe or effective for use in children with MDD.
To learn more about the conditions Abilify treats in children, talk with your doctor.
Here are answers to some frequently asked questions about Abilify.
Does Abilify give you energy? How will Abilify make you feel?
No, Abilify won’t make you feel more energetic than usual. In fact, Abilify may actually make some people feel more sleepy than usual.
Some drugs called stimulants may make you feel more energetic than usual. But Abilify isn’t a stimulant drug. Instead, it’s an antipsychotic drug.
If you have any questions about how Abilify may make you feel, see the “Abilify side effects” section or talk with your doctor or pharmacist.
Is Abilify a controlled substance?
No, Abilify is not a controlled substance. (Controlled substances are more likely than other medications to cause dependence.) Even so, your body may become dependent on Abilify.
With dependence, your body needs the drug in order to function like usual. Abilify may cause dependence because it affects hormones inside your brain. And once your body adjusts to the changes that Abilify causes, you may become dependent on the drug.
Because Abilify may cause dependence, it’s possible that you’ll have withdrawal symptoms if you stop taking it.
To learn more about this, see the “Abilify withdrawal and dependence” section. Also, talk with your doctor about how this medication may affect you.
Can Abilify be used to treat bipolar II disorder?
Yes, sometimes Abilify is prescribed off-label to treat bipolar II disorder. But keep in mind that Abilify isn’t approved by the Food and Drug Administration (FDA) to treat bipolar II disorder. (With off-label use, a drug that’s approved by the FDA for certain conditions is prescribed for another condition.)
On the other hand, Abilify is approved to treat manic or mixed episodes related to bipolar I disorder. Bipolar disorder affects your brain and causes you to have changes in your mood and behavior.
With bipolar I disorder, you may have manic episodes. During these episodes, you can feel very energetic or extremely irritable. And your thoughts may be racing, making it difficult for you to concentrate. It’s also possible to have mixed episodes with bipolar I disorder. With mixed episodes, you have both manic symptoms and depression symptoms at the same time. This causes changes in your mood that can be severe.
However, with bipolar II disorder, your most common symptom is major depression. With bipolar II disorder, you’ll also have hypomania, which is a less severe condition than the mania seen with bipolar I disorder.
It’s important to remember that Abilify is approved to treat manic or mixed episodes of bipolar disorder. Because people with bipolar II disorder mostly have depressive symptoms, Abilify may not work as well for them.
If you have questions about using Abilify to treat bipolar II disorder, talk with your doctor. They can recommend whether Abilify may be an option to treat your condition.
It’s possible that your body may become dependent on Abilify. But keep in mind that Abilify isn’t a controlled substance. (Controlled substances are more likely than other medications to cause dependence.)
With dependence, your body needs the drug in order to function like usual. Abilify may cause dependence because it affects hormones inside your brain. And once your body adjusts to the changes caused by Abilify, you may become dependent on the drug.
Because Abilify may cause dependence, it’s possible that you’ll have withdrawal symptoms if you stop taking the drug.
However, keep in mind that dependence on Abilify has not been studied in humans. So it’s not known for sure if everyone who takes the drug will become dependent on it.
It’s important to talk with your doctor about Abilify withdrawal and dependence if you have a history of drug misuse. Because this medication may cause dependence and withdrawal symptoms, your doctor may recommend a different medication for you that has a lower risk of these complications.
Withdrawal symptoms and withdrawal timeline of Abilify
The withdrawal symptoms that may occur in people who suddenly stop taking Abilify are not known for sure. Also, it is unknown how soon after stopping Abilify you’ll have withdrawal symptoms, or how long they’ll last.
Withdrawal symptoms of Abilify may include:
- dizziness
- nausea
- anxiety
- muscle twitches
- insomnia
- headache
- nausea
- increased heart rate
If you have questions about withdrawal symptoms from Abilify, talk with your doctor or pharmacist.
How to stop taking Abilify
If you’re planning to stop taking Abilify, talk with your doctor first about how to taper off the drug. With tapering, your doctor will slowly decrease your dose of the drug so that your body can adjust to the lower dose over time. Tapering off Abilify can help decrease your risk of withdrawal symptoms.
Keep in mind that the lowest strength of Abilify tablets is 2 mg. So if you’re taking 2 mg of Abilify daily and you’re planning to stop taking it, your doctor may just have you stop taking your daily dose.
Other drugs are available that can treat your condition. Some may be a better fit for you than others. If you’re interested in finding an alternative to Abilify, talk with your doctor. They can tell you about other medications that may work well for you.
- bupropion (Wellbutrin XL)
- venlafaxine XR (Effexor XR)
- brexpiprazole (Rexulti)
- quetiapine (Seroquel)
- lurasidone (Latuda)
- cariprazine (Vraylar)
- paliperidone (Invega)
- sertraline (Zoloft)
- amphetamine/dextroamphetamine (Adderall)
- fluoxetine (Prozac)
It is unknown exactly how Abilify works inside your brain. However, it’s believed that the drug may work on receptors (attachment sites) for certain brain chemicals. These brain chemicals include dopamine and serotonin.
Dopamine is important in regulating how you think and feel. And serotonin is important in controlling your mood and behavior.
It’s believed that certain mental health conditions may cause you to have too much dopamine or serotonin in your brain. Examples of these mental health conditions include schizophrenia, mania, irritability related to autism, and Tourette syndrome. And Abilify is approved to treat each of these conditions.
Abilify may work by balancing your dopamine and serotonin levels. This way, you don’t have too much or too little of the brain chemicals, which makes your thoughts and behaviors easier to control.
You may wonder how Abilify compares with other medications that are prescribed for similar uses. The following table gives an overview of how Abilify and Abilify Maintena compare.
Abilify | Abilify Maintena | |
Active drug | aripiprazole | aripiprazole |
Form | oral tablet | intramuscular injection |
Uses | • schizophrenia in adults and children ages 13 years and older • manic and mixed episodes related to bipolar I disorder in adults and children 10 years and older • depression in adults, in combination with other drugs • irritability that’s related to autism in children ages 6 years and older • Tourette syndrome in children ages 6 years and older | • schizophrenia in adults • bipolar I disorder in adults |
Because Abilify and Abilify Maintena both contain the same active drug, their mild and serious side effects are generally the same.
One exception is that while Abilify may cause headaches, Abilify Maintena does not cause them. Also, because Abilify Maintena is an injectable medication, you may have injection side effects with it. For example, you could experience pain at your injection site after receiving a dose of the drug.
To learn more about these drugs, including their potential side effects, see the prescribing information for Abilify and Abilify Maintena. Your doctor or pharmacist can also tell you more about these drugs.
Abilify and Rexulti may be prescribed for similar uses. The following table gives an overview of how these drugs compare.
Abilify | Rexulti | |
Active drug | aripiprazole | brexpiprazole |
Form | oral tablet | oral tablet |
Uses | • schizophrenia in adults and children ages 13 years and older • manic and mixed episodes related to bipolar I disorder in adults and children ages 10 years and older • depression in adults, in combination with other drugs • irritability that’s related to autism in children ages 6 years and older • Tourette syndrome in children ages 6 years and older | • schizophrenia in adults and children ages 13 years and older • MDD in adults, in combination with other drugs • agitation related to dementia due to Alzheimer’s disease in adults |
Abilify and Rexulti can cause similar side effects, but some different ones as well. To learn more about these drugs, including their potential side effects, see this article or the prescribing information for Abilify and Rexulti. Your doctor or pharmacist can also tell you more about these drugs.
Abilify and Latuda may be prescribed for similar uses. The following table below gives an overview of how these drugs compare.
Abilify | Latuda | |
Active drug | aripiprazole | lurasidone |
Form | oral tablet | oral tablet |
Uses | • schizophrenia in adults and children ages 13 years and older • manic and mixed episodes related to bipolar I disorder in adults and children ages 10 years and older • depression in adults, in combination with other drugs • irritability that’s related to autism in children ages 6 years and older • Tourette syndrome in children ages 6 years and older | • schizophrenia in adults and children ages 13 years and older • depressive episodes related to bipolar I disorder in adults and children ages 10 years and older • depressive episodes related to bipolar I disorder in adults, in combination with either lithium or valproate |
Abilify and Latuda can cause similar side effects, but some different ones as well. Read more about Abilify vs. Latuda or see the prescribing information for Abilify and Latuda. Your doctor or pharmacist can also tell you more about these drugs.
Abilify can interact with several other medications. It can also interact with certain foods. It’s not known to interact with any herbs or supplements. However, this doesn’t mean that interactions won’t be recognized in the future.
Before taking Abilify, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
The following table lists some of the medications, supplements, and foods that can interact with Abilify. This list does not contain all drugs that may interact with Abilify.
Medication interactions
The table below lists some of the types of drugs that may interact with Abilify.
Type of medication | Examples |
benzodiazepines | • lorazepam (Ativan) • diazepam (Valium) • alprazolam (Xanax) • clonazepam (Klonopin) |
selective serotonin reuptake inhibitors (SSRIs), a type of antidepressant | • paroxetine (Paxil) • fluoxetine (Prozac) |
drugs that affect the level of Abilify in your body | • itraconazole (Sporanox) • clarithromycin • quinidine • carbamazepine (Tegretol) • rifampin (Rifadin) |
certain blood pressure medications | • prazosin (Minipress) • doxazosin (Cardura) |
certain recreational or illegal drugs | • cannabis • heroin |
certain pain relievers | • morphine (Mitigo, MS Contin, others) • oxycodone (OxyContin, Roxicodone, others) • fentanyl (Actiq, Fentora, Sublimaze) |
Other interactions: Alcohol and food
If you drink alcohol, it may not be safe to consume while taking Abilify. If you have questions about the safety of drinking alcohol while taking Abilify, talk with your doctor or pharmacist.
Abilify is known to interact with grapefruit. Eating grapefruit or drinking grapefruit juice while you’re taking Abilify could cause the amount of the drug in your body to build up. Your doctor will recommend that you avoid grapefruit products during Abilify treatment.
If you have any questions about consuming grapefruit or any other foods with Abilify, talk with your doctor.
Learn more about Abilify interactions.
As with all medications, the cost of Abilify can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use.
Drug coupons: You can visit Optum Perks for price estimates of Abilify. These estimates are based on the use of Optum Perks coupons. Note: Optum Perks coupons cannot be used with insurance copays or benefits.
Financial and insurance assistance: Otsuka America Pharmaceutical, Inc., the manufacturer of Abilify, provides cost savings for this drug. To learn more, visit the manufacturer’s website.
Generic version: Abilify is available in a generic version called aripiprazole. A generic drug is an exact copy of the active ingredient in a brand-name medication. The generic is considered to be as safe and effective as the original drug. And generics tend to cost less than brand-name drugs. To find out how the cost of aripiprazole compares to the cost of Abilify, talk with your doctor or pharmacist.
Learn more about saving money on prescriptions.
If you can become pregnant or are breastfeeding, it’s important to consider whether Abilify is a safe choice for you.
Learn more about Abilify, pregnancy, and breastfeeding. If you have additional questions, talk with your doctor.
This drug comes with several precautions.
FDA warnings
This drug has boxed warnings. These are the most serious warnings from the Food and Drug Administration (FDA). A boxed warning alerts doctors and patients about drug effects that may be dangerous.
Increased risk of death in certain older people: Certain older people may have an increased risk of death when taking antipsychotic drugs, such as Abilify. Specifically, older people with psychosis that’s related to dementia (a condition involving memory loss) have this increased risk. Because of this risk, older people with these conditions should not take Abilify.
If you have any symptoms of dementia-related psychosis and you’re taking Abilify, talk with your doctor right away. They can recommend appropriate treatment options for your condition.
Increased risk of suicidal thoughts and behaviors in younger people: Abilify may increase the risk of suicidal thoughts and behaviors in children or adults ages 24 years and younger. Anyone who takes Abilify may be monitored by their doctor for new or worsening depression and suicidal thoughts or behaviors. If you’re taking Abilify, your doctor may recommend that your family members also watch for any changes in your mood.
If you’re having new or worsened depression, call your doctor right away. But if you’re having thoughts of harming yourself, call 911 or your local emergency service.
Help is out there
If you or someone you know is in crisis and considering suicide or self-harm, please seek support:
- Call or text the 988 Lifeline at 988 or chat at 988lifeline.org. Caring counselors are available to listen and provide free and confidential support 24/7.
- Text HOME to the Crisis Text Line at 741741 to connect with a volunteer crisis counselor for free and confidential support 24/7.
- Not in the United States? Find a helpline in your country with Befrienders Worldwide.
- Call 911 or your local emergency services number if you feel safe to do so.
If you’re calling on behalf of someone else, stay with them until help arrives. You may remove weapons or substances that can cause harm if you can do so safely.
If you’re not in the same household, stay on the phone with them until help arrives.
Other precautions
Before taking Abilify, talk with your doctor about your health history. Abilify may not be right for you if you have certain medical conditions or other factors affecting your health. Be sure to talk with your doctor if you have any of these conditions:
- seizures or convulsions
- suicidal thoughts and behaviors
- diabetes
- high or low blood pressure
- history of stroke or certain heart problems, including heart attack
- low white blood cell level
- problems with an enzyme called CYP2D6 that helps break down medications in the body
- previous allergic reaction to this or a similar drug
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.