The recommended trazodone dosage for major depressive disorder (MDD) is between 150 milligrams (mg) and 400 mg. Trazodone is an oral tablet that you typically take in divided doses. It is important to take the trazodone dosage as your doctor prescribes.
Trazodone is a generic medication that belongs to a drug class called serotonin receptor antagonist and reuptake inhibitor (SARI). Trazodone is not available in a brand-name version. Previously, the brand name was Desyrel, but it is discontinued now.
This article describes the dosages of trazodone, as well as its strengths and how to take it. To learn more about trazodone, including its uses and side effects, see this trazodone overview article.
Boxed warning: Risk of suicidal thoughts and behaviors
Trazodone has a boxed warning about the risk of suicidal thoughts and behaviors. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous.
Antidepressants can increase the risk of suicidal thoughts and behaviors in people ages 24 years or younger. However, trazodone is not approved for use in people under the ages of 18 years.
If you have thoughts of suicide, call 911 or your local emergency number. In the United States, you can also call the Suicide and Crisis Lifeline at 988 or text HOME to the Crisis Text Line at 741741.
To learn more about this warning, talk with your doctor or pharmacist.
Show MoreYour doctor will likely start you on a low dosage and adjust it over time to reach the right amount for you. They’ll ultimately prescribe the smallest dosage that provides the desired effect.
The following table highlights the basics of trazodone’s dosage. All doses are listed in milligrams (mg).
Always be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs. In some cases, doctors may adjust your dosage from those mentioned here.
| Trazadone dosage | |
|---|---|
| Form | oral tablet |
| Strengths | • 50 milligrams (mg) • 100 mg • 150 mg • 300 mg |
| Dose | • starting dose is 150 mg per day • your doctor may increase the dose by 50 mg per day every 3 or 4 days until you reach the desired effect |
Keep reading for more dosage details.
Trazodone forms
- Trazodone is available as an oral tablet.
Trazodone strengths
- Trazodone comes in four strengths:
- 50 mg
- 100 mg
- 150 mg
- 300 mg
Trazodone is approved to treat major depressive disorder (MDD). The typical trazodone dosage for adults with MDD condition is between 150 mg and 400 mg.
If you are receiving treatment in a hospital or depression treatment center for severe depression or depression that lasts a long time, the maximum dosage of trazodone may be increased to 600 mg while you are in that treatment facility.
The dosage of trazodone may vary depending on your condition and the severity of your symptoms.
Always follow your prescribing doctor’s instructions. Notify them if you experience any side effects that may prevent you from taking your medication. Do not stop taking trazodone without consulting with your healthcare professional. Your doctor will help you taper off the medication gradually.
How long do you take trazodone?
Trazodone is usually a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long term.
Do not take more trazodone than your doctor prescribes, as this can lead to harmful effects.
Symptoms of trazodone overdose
Symptoms caused by an overdose of trazodone can include:
- vomiting
- drowsiness
- seizures
- atypical heart rhythm, such as QT prolongation
- respiratory arrest (when you stop breathing)
- priapism (prolonged, painful erection)
What to do in case you take too much trazodone
Call your doctor right away if you think you’ve taken too much trazodone. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.
Below are answers to some commonly asked questions about trazodone’s dosage.
What is the dosage of trazodone for sleep?
Trazodone is only approved by the Food and Drug Administration (FDA) for MDD. It is not approved to treat insomnia or other sleep-related conditions. However, some healthcare professionals may prescribe trazodone off-label for sleep. Off-label use is when a drug is prescribed for a purpose other than what it’s approved for.
If you have questions about trazodone for sleep, talk with your doctor. They can provide you with information on dosing, such as the minimum and maximum dosages for sleep.
What is the dosage of trazodone for anxiety?
Trazodone is only approved by the FDA for MDD. It is not approved to treat anxiety. In some cases, your healthcare professional may prescribe trazodone off-label for anxiety. Off-label use is when a drug is prescribed for a purpose other than what it’s approved for.
If you have questions about trazodone for anxiety, talk with your doctor. They can provide you with information on dosing and other details about the drug.
Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
